Pharmacological action Clobetasol 0.05%
Clobetasol SCS for outdoor use. Anti-inflammatory and antiallergic action. Eliminates edema, flushing and itching at the site of application. Highly glucocorticosteroid for topical application. Prevents the accumulation of neutrophils boundary, reduces the inflammatory exudation and production of lymphokines, inhibits the migration of macrophages, reduces the intensity of infiltration and granulation. It has a local anti-inflammatory, anti-inflammatory, antipruritic, antiallergic and antiexudative effects.
Indications Clobetasol 0.05%
Psoriasis (excluding widespread plaque psoriasis); eczema: lichen planus, discoid lupus erythematosus, other skin diseases resistant to treatment less active steroids.
Application of Clobetasol 0.05%
Ointment or cream should be applied very thinly to the affected skin 1 or 2 p / day until improvement. With a very persistent skin lesions, especially in the case of hyperkeratosis, anti-inflammatory effect can be enhanced by clobetasol use of occlusive dressings-tion. It is sufficient to occlude a single night. In the absence of the effect of the prima, equation of the drug for 2-4 weeks is necessary to consult a specialist to confirm the diagnosis. The drug is recommended for short term use. If necessary, may conduct short refresher courses. If you want long-term treatment is recommended to use less drastic means. When applying the drug to the eye lid is necessary to take precautions to clobetasol not hit in the eye. In the treatment of diseases such as psoriasis, lupus discoid lupus, eczema should be borne in mind that on the face appear more severe atrophic changes than other parts of the body. Use of the drug in the treatment of psoriasis requires careful patient monitoring to prevent relapse, development of tolerance, the emergence of widespread pustular psoriasis and development of local or systemic reaction due to violations of the barrier function of skin. If you change the skin of occlusive dressings should be clean. In the case of accession of clobetasol infection should be discontinued and appropriate therapy to appoint. If signs of hypersensitivity to the drug treatment should be immediately discontinued.
Side effects of Clobetasol 0.05%
Local reactions: with prolonged and intensive treatment – atrophic skin changes: atrophic band, skin thinning, expansion of surface blood vessels. Systemic reactions: suppression of pituitary and adrenal cortex. If the 1-week dose of the drug in the treatment of adult patients less than 50 grams, this systemic effect is usually temporary in nature and function of the pituitary and adrenal cortex to normal after stopping the course of steroid therapy. The same applies to the treatment of children with these drugs who are assigned to a smaller dose. The use of occlusive dressings increases the absorption of topical corticosteroids. In infants, the diaper may act as occlusive dressings.
Contra-Clobetasol 0.05%
Nodular prurigo (Hyde), acne vulgaris, acne rosacea, perioral dermatitis, primary viral infection of the skin (herpes simplex, varicella), the primary bacterial infection of the skin, primary cutaneous fungal lesions, peri-anal and genital itching, dermatitis in children 1 year, including dermatitis and irritation caused by diapers, hypersensitivity to the drug. There is no sufficient data on the safety of the drug during pregnancy.
Overdose Clobetasol 0.05%
Symptoms: The symptoms of Cushing.
Treatment: removal of preparation.
Precautions Clobetasol 0.05%
Avoid contact with eyes (may increase intraocular pressure). Before applying a fresh bandage the skin should be clean, because heat and humidity caused by tight bandages, contribute to the emergence of bacterial infection.
